
why make this recipe
Cattle Drive Casserole is a hearty and comforting dish that brings together many flavors in one easy meal. It’s great for busy weeknights, family gatherings, or casual get-togethers. This casserole has everything you need: protein, vegetables, and delicious cheesy goodness. Plus, it’s simple to prepare and can easily feed a crowd, making it a perfect choice for any occasion!
how to make Cattle Drive Casserole
Ingredients:
- 1.5 pounds Lean Ground Beef
- 1 Red Bell Pepper, seeded and chopped
- 1 Yellow Onion, chopped
- 1 ounce Taco Seasoning Mix
- 2 ½ cups Biscuit Mix, like Bisquick
- 1 cup Water
- Cooking Spray, like Pam
- ½ cup Sour Cream
- ½ cup Mayonnaise
- 4 ounces Diced Green Chiles, drained
- 1 ½ cups Cheddar Cheese, Fiesta Blend, shredded, divided
- 1 teaspoon Garlic Powder
- ½ cup Salsa, mild
Directions:
- Preheat the oven to 350℉.
- In a skillet, cook the ground beef over medium heat until it is no longer pink. Drain any excess fat.
- In a mixing bowl, combine the biscuit mix and water to form a dough. Press this dough into a sprayed casserole dish and bake for 5-8 minutes.
- In the skillet with the beef, add the chopped onions and red bell pepper. Cook for about 4 minutes until the vegetables are slight soft. Mix in the taco seasoning.
- Spread the beef mixture evenly over the baked biscuit layer in the casserole dish.
- In a separate bowl, mix the sour cream, mayonnaise, green chiles, ¾ cup of cheese, and garlic powder. Spread this mixture over the beef layer.
- Add spoonfuls of salsa on top, then sprinkle the remaining cheese over the casserole.
- Bake the casserole for 30 minutes or until hot and bubbly.
- Serve hot and enjoy!
how to serve Cattle Drive Casserole
Cattle Drive Casserole is best served warm. You can serve it in generous portions, perhaps alongside a fresh green salad or some tortilla chips for extra crunch. Feel free to add extra salsa or sour cream for those who like a bit more flavor on their plates!
how to store Cattle Drive Casserole
To store leftover Cattle Drive Casserole, let it cool down completely. Place it in an airtight container and refrigerate it for up to 3 days. If you want to keep it longer, you can freeze it for up to 3 months. Just be sure to wrap it well to prevent freezer burn!
tips to make Cattle Drive Casserole
- For a spicier kick, try using a hot salsa or add some jalapeños to the beef mixture.
- You can substitute ground turkey or chicken for a lighter option.
- If you don’t have diced green chiles, you can use chopped jalapeños or skip them altogether.
- Experiment with different types of cheese, like pepper jack or Monterey Jack, to change up the flavor.
variation
Feel free to add more vegetables such as corn, black beans, or zucchini to enhance the nutritional value of the casserole. You can also top it with crushed tortilla chips before baking for added crunch!
FAQs
Can I prepare Cattle Drive Casserole ahead of time?
Yes! You can assemble the casserole the night before and store it in the refrigerator. Just bake it when you’re ready to serve.
Can I use a different type of meat?
Absolutely! Ground turkey, chicken, or even meat alternatives can work well in this recipe.
How can I make this dish vegetarian?
You can replace the ground beef with cooked lentils, mushrooms, or a meat substitute like crumbled tofu or veggie crumbles. Adjust the flavors as needed.

Cattle Drive Casserole
Ingredients
Main Ingredients
- 1.5 pounds Lean Ground Beef Can substitute with ground turkey or chicken.
- 1 medium Red Bell Pepper, seeded and chopped
- 1 medium Yellow Onion, chopped
- 1 ounce Taco Seasoning Mix
- 2.5 cups Biscuit Mix, like Bisquick
- 1 cup Water
- Cooking Spray like Pam For greasing the casserole dish.
- 0.5 cup Sour Cream
- 0.5 cup Mayonnaise
- 4 ounces Diced Green Chiles, drained Can substitute with chopped jalapeños or omit.
- 1.5 cups Cheddar Cheese, Fiesta Blend, shredded, divided Can experiment with different cheeses.
- 1 teaspoon Garlic Powder
- 0.5 cup Salsa, mild For added flavor.
Instructions
Preparation
- Preheat the oven to 350℉.
- In a skillet, cook the ground beef over medium heat until it is no longer pink. Drain any excess fat.
- In a mixing bowl, combine the biscuit mix and water to form a dough. Press this dough into a sprayed casserole dish and bake for 5-8 minutes.
- In the skillet with the beef, add the chopped onions and red bell pepper. Cook for about 4 minutes until the vegetables are slightly soft. Mix in the taco seasoning.
Assembly
- Spread the beef mixture evenly over the baked biscuit layer in the casserole dish.
- In a separate bowl, mix the sour cream, mayonnaise, green chiles, ¾ cup of cheese, and garlic powder. Spread this mixture over the beef layer.
- Add spoonfuls of salsa on top, then sprinkle the remaining cheese over the casserole.
Baking
- Bake the casserole for 30 minutes or until hot and bubbly.
Serving
- Serve hot and enjoy! Best served warm alongside a fresh green salad or tortilla chips.